This system is especially suitable for Western blotting analysis. High sensitive chemiluminescent detection was designed to compete with the X-ray films. A wide variety of excitation light sources enables this system to capture various fluorescent images, including in vivo imaging or fluorescent Western blotting, also. New Super CCD Area Type Imaging Chip - This system is especially suitable for Western blotting analysis.High sensitive chemiluminescent detection was designed to compete with the X-ray films. Image acquire and digitize can capture both chemiluminescence and digitized marker image by one click. New Super CCD Area Type Imaging Chip - The higher sensitivity of Fujifilm's new CCD provides improved faint-light image capture with outstanding image clarity. The new chip contains 3.2M pixels of which 3.15M contribute to actual imaging. The increased pixel size results from the use of octagonal-shaped photodiodes, which capture a great deal of light. The superior image sensing capability of the new chip results in ultra-high resolution image files of up to 6.3M pixels (3,072 x 2,048 pixels). Super CCD - By rotating pixels 45 degrees to form an interwoven layout, the Super CCD's pixel pitch in the horizontal and vertical directions is narrower than in the diagonal direction, achieving higher horizontal and vertical resolution. Conventional CCD - With conventional interline CCDs, pixel pitch in the diagonal direction is narrower than in the horizontal and vertical directions, resulting in higher diagonal resolution. New Binning Mode - The LAS-4000 features a new binning mode, which allows users to effectively increase the pixel size and, therefore, the imaging sensitivity of the system. Additionally, the process significantly enhances the signal-to-noise ratio. The system allows four binning settings: 1x2 (standard), 2x4 (high), 4x8 (super) and 8x16 (ultra). Images obtained in the binning mode are further enhanced by software-based pixel supplement to compensate for any loss in resolution. The binning mode of the LAS-4000 allows researchers to select from four binning settings to enhance both imaging sensitivity and image resolution. With the Image Reader Pro software, High resolution, High binning, Super binning and Ultra binning images can be obtained in addition to the standard High Super and Ultra images. Exposure Options - The extremely fast, electronically cooled, high-resolution camera component allows long exposure times in any laboratory setting. Exposures can be set from 1/100th of a second to 30 hours to meet a wide range of imaging conditions. The 30-hours exposure function allows over-night exposures on very dark images. New Filter Options - A 5-position filter turret is mounted in front of the lens, which allows convenient, electrically controlled filter selection in less than ten seconds. With Image Reader software, the user has control over three standard filters (605DF40 for EtBr, Y515 for SYBR® Green and 510DF10 for GFP), a fourth filter position for chemiluminescence and a fifth user-specified filter for fluorescence. With Image Reader software, the user has full control over four filter types and positions. Other than the above, 575DF20 filter was prepared for green LED, L41 filter was prepared for UV LED, and IR785 filter was prepared for IR LED. Additional Light Sources - The number of light sources on the LAS-4000 system has been increased to eight, including UV transilluminator, white transilluminator, epi-blue illuminator, epi-green illuminator, epi-red illuminator, epi-UV illuminator, epi-IR illuminator, epi-white illuminator. With ImageReader software, the user has control over eight light sources (UV transilluminator, white transilluminator, epi-blue illuminator, epi-green illuminator, epi-red illuminator, epi-UV illuminator, epi-IR illuminator and epi-white illuminator). Sampling Convenience ­ The LAS-4000 accommodates samples up to 25 x 25cm in size with an optional wide view lens. Various types of trays are prepared such as an EPI Tray for chemiluminescence and epi-illuminator, a DIA Tray for UV trans-illuminator , a white-DIA Tray for white trans-illuminator such as CBB stained gel, and a non-parallax (NP) Tray for up to two titer plates. The NP tray includes a Fresnel lens located between the titer plate and the lens, which eliminates parallax in each of the 96 titer plate wells. NP Tray is designed for the detection of chemiluminescence. Simplified User Interface - The system functions of the LAS-4000 are controlled remotely through either a Mac® or Windows® software application via a standard USB2.0 interface. Image capture and analysis software is provided. The newly simplified user interface allows researchers to spend more time in research and less time in system integration and maintenance. Light-tight operation - The light-tight dark box affords highly sensitive imaging from a variety of light sources in an ordinary lab. After placing the sample tray in the dark box and closing the light-tight door, all imaging functions are controlled remotely from the PC. With the keyboard and monitor, the researcher conveniently adjusts focus, selects the appropriate filter and sets the exposure to capture the image. External cable/tube insertion port ­ The analyzer has a port for inserting temperature adjustment/anesthesia cables and tubes. The self-explanatory and user-friendly software allows specification of all image capture parameters, including sensitivity, resolution and image methods. The software automatically carries out all image correction functions. In increment mode, the signal increase is shown in real time, by capturing and automatically displaying up to 16 images. With this software users can create their own settings and methods. A photograph of the sample can be made and overlaid with the signal image. To LAS-4000