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Title Author(s) Journal Year Type of formulation Summary
CellSaic, a Cell Aggregate-like Technology Using Recombinant Peptide Pieces for MSC Transplantation Nakamura K. Current Stem Cell Research & Therapy, 2018, Vol.13, No.00 2018 CellSaic
(μ piece x cells)
Introductino of CellSaic technolgy for MSC transplantation
Petaloid Recombinant Peptide Enhances in Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells Naritomi M., Mizuno M.,Katano H., Ozeki N., Otabe K., Komori K., Fujii S., Ichinose S., Tsuji K., Koga H., Muneta T., Sekiya I. Journal of Orthopaedic Research 9999:1-8, 2018. 2018 μ piece X cells The petaloid shaped μ pieces promotes in vitro cartilage formation of synovial MSCs
The therapeutic effects of adipose-derived stem cells and recombinant peptide pieces on mouse model of DSS colitis Iwazawa R., Kozakai S., Kitahashi T., Nakamura K., Hata K. Cell Transplantation 2018, vol.27(9) 1390-1400 2018 CellSaic
(μ piece x cells)
The therapeutic effects of tranplanted CellSaic, composed of human and canine adipose-derived cells and μ pieces on mouse model of DSS induced colitis
Therapeutic effects of a recombinant human collagen peptide bioscaffold with human adipose-derived stem cells on impaired wound healing after radiotherapy Mashiko T., Takada H., Wu SH., Kanayama K., Feng J., Tashiro K., Asahi R., Sunaga A., Hoshi K., Kurisaki A., Takato T., Yoshimura K. J Tissue Eng Regen Med. 2018 Jan 26. (available online) 2018 sponge Improvement of skin wound healing after radiation therapy in mice by cellnest sponge with human adipose-derived stem cells loaded
Human recombinant peptide (RCP) sponge enables novel, less invasive cell therapy for ischemic stroke Michiyuki M., Kentaro N., Hideo S., Tomohiro Y., Masaki I., Hisayasu S., Masahito K., Toshiya O., Tasuku S., Kiyohiro H., and Satoshi K. Stem Cells International. 2018, 4829534 2018 sponge Ischemic stroke therapy in rats by cellnest sponge with rat bone marrow-derived stem cells loaded
The Optimization of the Prevascularization Procedures for Improving Subcutaneous Islet Engraftment Uematsu SS., Inagaki A., Nakamura Y., Imura T., Igarashi Y., Fathi I., Miyagi S., Ohuchi N., Satomi S., Goto M. Transplantation. 2018 Mar;102(3):387-395. 2018 sponge Improvement in efficacy of islet transplantation by cellnest sponges prevascularized in mouse subcutaneous space
An Injectable Recombinant Collagen I Peptide–Based Macroporous Microcarrier Allows Superior Expansion of C2C12 and Human Bone Marrow-Derived Mesenchymal Stromal Cells and Supports Deposition of Mineralized Matrix Confalonieri, D., La Marca, M., van Dongen, E. M. W. M., Walles, H., & Ehlicke, F. Tissue Eng Part A. 2017 Sep;23(17-18):946-957. 2017 microsphere Effects of crosslinking methods of porous cellnest microsphere on cell growth
Biomineralization of Recombinant Peptide Scaffolds: Interplay among Chemistry, Architecture, and Mechanics Pawelec, K. M., & Kluijtmans, S. G. J. M. ACS Biomaterials Science & Engineering, 3(6), 1100–1108. 2017 sponge Effects of the pore size of mineralized cellnest sponges with vertical pores on substance diffusion and cell adhesion properties
Biomineralized Recombinant Collagen-Based Scaffold Mimicking Native Bone Enhances Mesenchymal Stem Cell Interaction and Differentiation Ramírez-Rodríguez, G. B., Montesi, M., Panseri, S., Sprio, S., Tampieri, A., & Sandri, M. Tissue Eng Part A. 2017 Dec;23(23-24):1423-1435. 2017 sponge Improvement of cell growth and differentiation by the addition of Magnesium in mineralized cellnest sponge
Ice-templating of anisotropic structures with high permeability Pawelec, K. M., van Boxtel, H. A., & Kluijtmans, S. G. J. M. Materials Science and Engineering: C, 76, 628–636. 2017 sponge Preparation of cellnest sponges with controlled pore size by ice-templating method
New bioactive bone-like microspheres with intrinsic magnetic properties obtained by bio-inspired mineralisation process Fernandes Patrício, T. M., Panseri, S., Sandri, M., Tampieri, A., & Sprio, S. Materials Science and Engineering: C, 77, 613–623. 2017 microsphere Synthesis of magnetic cellnest microsphere by crystallization of hydroxyapatite doped with metal on cellnest
Osteogenesis and mineralization of mesenchymal stem cells in collagen type I-based recombinant peptide scaffolds Pawelec, K. M., Confalonieri, D., Ehlicke, F., van Boxtel, H. A., Walles, H., & Kluijtmans, S. G. J. M. Journal of Biomedical Materials Research Part A, 105(7), 1856–1866. 2017 sponge Effects of crosslinking methods of cellnest sponges on osteogenesis properties
Biomimetic mineralization of recombinant collagen type I derived protein to obtain hybrid matrices for bone regeneration Ramírez-Rodríguez, G. B., Delgado-López, J. M., Iafisco, M., Montesi, M., Sandri, M., Sprio, S., & Tampieri, A. Journal of Structural Biology, 196(2), 138–146. 2016 cellnest Establishment of a method to mineralize cellnest
Development of recombinant collagen-peptide-based vehicles for delivery of adipose-derived stromal cells Parvizi, M., Plantinga, J. A., van Speuwel-Goossens, C. A. F. M., van Dongen, E. M. W. M., Kluijtmans, S. G. J. M., & Harmsen, M. C. Journal of Biomedical Materials Research Part A, 104(2), 503–516. 2016 cellnest
Effects of cellnest and microsphere on gene expression petterns in adipose-derived stem cells
Introduction to a new cell transplantation platform via recombinant peptide petaloid pieces and its application to islet transplantation with mesenchymal stem cells Nakamura, K., Iwazawa, R., & Yoshioka, Y. Transplant International, 29(9), 1039–1050. 2016 CellSaic Improvement of blood glucose level in mice by the combination of CellSaic and islet
Hyaluronic acid-recombinant gelatin gels as a scaffold for soft tissue regeneration Tuin, A., Zandstra, J., Kluijtmans, S. G., Bouwstra, J. B., Harmsen, M. C., & van Luyn, M. J. A. European Cells and Materials, 24, 320–330. 2012 cellnest
(as additive)
Stroma formation and cellnest degradation behavior in rats after the implantation of hyaluronic acid gels with cellnest incorporated
Recombinant Gelatin Microspheres: Novel Formulations for Tissue Repair? Tuin, A., Kluijtmans, S. G., Bouwstra, J. B., Harmsen, M. C., & Van Luyn, M. J. A. Tissue Engineering Part A, 16(6), 1811–1821. 2010 microsphere Establishment of a preparation method of cellnest microsphere
A new fluorescent imaging of renal inflammation with RCP Nakamura, K., & Tabata, Y. Journal of Controlled Release, 148(3), 351–358. 2010 cellnest Accumulation of cellnest in renal inflammation site in mice


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